Cymbalta, panic attacks and anxiety

Duloxetine hydrochloride (brand names: Cymbalta/Yentreve and in parts of Europe known as Xeristar) is a medically used drug that primarily targets major depressive disorders (MDD), pain related to diabetic peripheral neuropathy and stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company.

Duloxetine is labeled an SNRI for serotonin norepinephrine reuptake inhibitor.

Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. Its behavior contrasts to most other dual-reuptake inhibitors in that Ki values are nearly 1:1.

Duloxetine is thought to lack affinity for monoamine receptors within the central nervous system.

While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours. Administration with food may delay the maximum concentration (Cmax) by approximately 4 hours (from 6 to 10 hours), and it may also decrease the extent of absorption (AUC) by 10%.

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